Clinical manifestations and imaging features of white matter demyelination in older patients

• Published in: Journal of international medical research Vol. 48; no. 11; p. 300060520966806
• Main Authors: Li, Jian, Zhao, Yi-Ming
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.2020; Sage Publications Ltd; SAGE Publishing
• Subjects: Aged; Brain diseases; Demyelinating Diseases - diagnostic imaging; Female; Humans; Magnetic Resonance Imaging; Male; Medical diagnosis; Multiple Sclerosis; Older people; Retrospective Clinical Research Report; White Matter - diagnostic imaging; clinical diagnosis; dizziness; Magnetic resonance imaging; imaging report; demyelinating degeneration of white matter; headache; paroxysmal numbness and weakness of unilateral limb
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060520966806

Objective To investigate the clinical manifestations and imaging features of older patients with white matter demyelination diagnosed by magnetic resonance imaging (MRI). Methods Ninety-six patients with leukoaraiosis diagnosed by MRI were divided by their clinical diagnoses into a demyelinating group (40 cases) and a non-demyelinating group (56 cases). The imaging and clinical features of the patients in the two groups were analyzed. Results Compared with the non-demyelinating group, there were significantly more women in the demyelinating group than men. There was no significant difference in age between the two groups. Of the 37 cases who had an imaging report of “white matter demyelination and multiple sclerosis,” 36 cases had a clinical diagnosis in accordance with white matter demyelination (97.3%). Of the 59 cases who had an imaging report of “white matter demyelination”, only four cases had a clinical diagnosis in accordance with demyelination (6.8%). Conclusion In older patients with headaches, vertigo, other head symptoms, and unilateral numbness as the chief complaints, a clinical diagnosis of demyelinating disease is very unlikely when the imaging report states white matter demyelination only.