D-Dimer Predicts Disease Severity but Not Long-Term Prognosis in Acute Pulmonary Embolism

D-dimer might be correlated with prognosis in pulmonary embolism (PE). The predictive value of plasma D-dimer for disease severity and survival was investigated in the lowest and highest D-dimer quartile among 200 patients with PE. Patients with high D-dimers were significantly more often hypotensiv...

Full description

Saved in:
Bibliographic Details
Published inClinical and applied thrombosis/hemostasis Vol. 25; p. 1076029619863495
Main Authors Geissenberger, Fabian, Schwarz, Florian, Probst, Michael, Haberl, Sabine, Gruetzner, Stefanie, Kroencke, Thomas, von Scheidt, Wolfgang, Berghaus, Thomas M.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 12.07.2019
SAGE PUBLICATIONS, INC
SAGE Publishing
Subjects
Acute Disease
Aged
Embolisms
Female
Fibrin Fibrinogen Degradation Products - analysis
Health risk assessment
Humans
Hypotension - blood
Hypoxia - blood
Male
Medical prognosis
Middle Aged
Original
Predictive Value of Tests
Prognosis
Pulmonary Embolism - blood
Pulmonary Embolism - diagnosis
Pulmonary embolisms
Tachycardia - blood
D-dimer
risk stratification
pulmonary embolism
disease severity
prognosis
Online AccessGet full text

Cover

More Information
Summary:D-dimer might be correlated with prognosis in pulmonary embolism (PE). The predictive value of plasma D-dimer for disease severity and survival was investigated in the lowest and highest D-dimer quartile among 200 patients with PE. Patients with high D-dimers were significantly more often hypotensive (P = .001), tachycardic (P = .016), or hypoxemic (P = .001). Pulmonary arterial obstruction index (PAOI) values were significantly higher in the high D-dimer quartile (P < .001). Elevated troponin I (TNI) levels (P < .001), simplified PE severity indices ≥1 (P < .001), right-to-left ventricular (RV/LV) diameter ratios ≥1 (P < .001), and thrombolysis (P = .001) were more frequent in the high D-dimer quartile. D-dimer was associated with RV/LV ratios ≥1 (P = .021), elevated PAOI (P < .001) or TNI levels (P < .001), hypotension (P < .001), tachycardia (P = .003), and hypoxemia (P < .001), but not with long-term all-cause mortality. D-dimer predicts disease severity but not long-term prognosis in acute PE, possibly due to a more aggressive treatment strategy in severely affected patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029619863495