Endothelial progenitor cells in age-related vascular remodeling

Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved...

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Published inCell transplantation Vol. 27; no. 5; pp. 786 - 795
Main Authors Yang, Jin-Xiu, Pan, Yan-Yun, Wang, Xing-Xiang, Qiu, Yuan-Gang, Mao, Wei
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.05.2018
Sage Publications Ltd
SAGE Publishing
Subjects
Age
Aging - physiology
Animals
Arteries
Endothelial cells
Endothelial Progenitor Cells - physiology
Humans
Models, Biological
Progenitor cells
Reviews
Stem cells
Vascular Remodeling - physiology
vascular remodeling
age
Endothelial progenitor cell
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Summary:Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima. Meanwhile, other findings suggest that EPCs may be involved in the pathogenesis of age-related vascular remodeling. This review is presented to summarize the characteristics of EPCs and age-related vascular remodeling. In addition, the role of EPCs in age-related vascular remodeling and possible solutions for improving the therapeutic effects of EPCs in the treatment of age-related diseases are discussed.
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ISSN:0963-6897
1555-3892
1555-3892
DOI:10.1177/0963689718779345