Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions

• Published in: Frontiers in immunology Vol. 11; p. 202
• Main Authors: Wang, Zixi, Guan, Di, Wang, Shu, Chai, Louis Yi Ann, Xu, Shengli, Lam, Kong-Peng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.02.2020
• Subjects: anti-tumor; Antibodies - immunology; Antibodies - pharmacology; Blood Donors; CD16; Cell Degranulation; cell metabolism; Cells, Cultured; Cytotoxicity, Immunologic - drug effects; Fas Ligand Protein - metabolism; glycolysis; Glycolysis - drug effects; GPI-Linked Proteins - immunology; Humans; Immunology; Interferon-gamma - biosynthesis; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Ligands; Lymphocyte Activation - drug effects; natural killer cells; NK Cell Lectin-Like Receptor Subfamily K - metabolism; NKG2D; Oxidative Phosphorylation - drug effects; Receptors, IgG - immunology; Receptors, Natural Killer Cell - metabolism; anti-tumor; natural killer cells; CD16; NKG2D; cell metabolism; glycolysis

Natural killer (NK) cells are innate lymphocytes that directly kill tumor and pathogen-infected cells upon activation by cytokines and NK cell receptors (NKRs) without previous sensitization. It is known that cell metabolism affects the differentiation and effector functions of immune cells. For ins...