White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker

The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume. Thirty-six patients with localized testicular cancer with a mean age...

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Bibliographic Details
Published inInternational Brazilian Journal of Urology Vol. 42; no. 1; pp. 53 - 59
Main Authors Yuksel, Ozgur Haki, Verit, Ayhan, Sahin, Aytac, Urkmez, Ahmet, Uruc, Fatih
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira de Urologia 01.01.2016
Subjects
Adult
Biomarkers, Tumor
Biomarkers, Tumor - blood
Case-Control Studies
Hemoglobins - analysis
Humans
Lymphocyte Count
Lymphocytes
Male
Middle Aged
mouse [Supplementary Concept]
Neoplasms, Germ Cell and Embryonal - blood
Neoplasms, Germ Cell and Embryonal - diagnosis
Neoplasms, Germ Cell and Embryonal - pathology
Neutrophils
NLR protein
Original
Prognosis
Reference Values
Reproducibility of Results
Retrospective Studies
ROC Curve
Statistics, Nonparametric
Testicular Neoplasms
Testicular Neoplasms - blood
Testicular Neoplasms - diagnosis
Testicular Neoplasms - pathology
Tumor Burden
Varicocele - blood
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Summary:The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume. Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts. White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all). Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).
Bibliography:CONFLICT OF INTEREST
None declared.
ISSN:1677-5538
1677-6119
1677-6119
1677-5538
DOI:10.1590/S1677-5538.IBJU.2014.0593