From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or Combating Neospora caninum Infection in Different Susceptible Hosts

• Published in: Pathogens (Basel) Vol. 9; no. 5; p. 384
• Main Authors: Fereig, Ragab M, Nishikawa, Yoshifumi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 16.05.2020; MDPI AG
• Subjects: immunity; infection; Neospora caninum; neosporosis; Review; signaling pathways; infection; signaling pathways; immunity; neosporosis; Neospora caninum
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens9050384

is an intracellular protozoan parasite affecting numerous animal species. It induces significant economic losses because of abortion and neonatal abnormalities in cattle. In case of infection, the parasite secretes numerous arsenals to establish a successful infection in the host cell. In the same context but for a different purpose, the host resorts to different strategies to eliminate the invading parasite. During this battle, numerous key factors from both parasite and host sides are produced and interact for the maintaining and vanishing of the infection, respectively. Although several reviews have highlighted the role of different compartments of the immune system against infection, each one of them has mostly targeted specific points related to the immune component and animal host. Thus, in the current review, we will focus on effector molecules derived from the host cell or the parasite using a comprehensive survey method from previous reports. According to our knowledge, this is the first review that highlights and discusses immune response at the host cell-parasite molecular interface against infection in different susceptible hosts.