Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 15
• Main Authors: Stäb, F., Bahner, U., Fazeli, G., Stürmer, M., Sebekova, Katerina, Heidland, A.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; Advanced glycation end products; Aged; Aged, 80 and over; Biological markers; C-Reactive Protein - metabolism; Case-Control Studies; Diabetes Mellitus - blood; Diabetes Mellitus - pathology; Female; Glycation End Products, Advanced - blood; Humans; Inflammation; Inflammation - blood; Inflammation - complications; Inflammation - pathology; Insulin resistance; Male; Middle Aged; Mortality; Older people; Oxidative Stress; Physiological aspects; Vitamin D; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - pathology; Vitamin deficiency
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2015/958097

Objectives. In diabetes accumulated advanced glycation end products (AGEs) are involved in the striking cardiovascular morbidity/mortality. We asked whether a hypovitaminosis D associates with an increased formation and toxicity of AGEs in diabetes. Methods. In 276 diabetics (160 M/116 F, age: 65.0±13.4; 43 type 1,T1DM, and 233 type 2 patients, T2DM) and 121 nondiabetic controls (60 M/61 F; age: 58.6±15.5 years) routine biochemistry, levels of 25-hydroxyvitamin D3 (25-(OH)D), skin autofluorescence (SAF), plasma AGE-associated fluorescence (AGE-FL), Nε-(carboxymethyl)lysine (CML), soluble receptor for AGEs (sRAGE), soluble vascular adhesion protein-1 (sVAP-1), high sensitive C-reactive protein (hs-CRP), and renal function (eGFR) were determined. Results. In the diabetics SAF and AGE-Fl were higher than those of the controls and correlated with age, duration of diabetes, and degree of renal impairment. In T2DM patients but not in T1DM the age-dependent rise of SAF directly correlated with hs-CRP and sVAP-1. 25-(OH)D levels in diabetics and nondiabetics were lowered to a similar degree averaging 22.5 ng/mL. No relationship between 25-(OH)D and studied markers except for sVAP-1 was observed in the diabetics. Conclusion. In diabetics hypovitaminosis D does not augment accumulation of AGEs and studied markers of microinflammation and oxidative stress except for sVAP-1.