Danger signals in stroke and their role on microglia activation after ischemia

Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate im...

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Bibliographic Details
Published inTherapeutic advances in neurological disorders Vol. 11; p. 1756286418774254
Main Authors Gülke, Eileen, Gelderblom, Mathias, Magnus, Tim
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2018
SAGE PUBLICATIONS, INC
SAGE Publishing
Subjects
Innate immunity
Ischemia
Review
peroxiredoxin
Hsp
purines
HMGB1
stroke
microglia
DAMPs
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Summary:Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.
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ISSN:1756-2864
1756-2856
1756-2864
DOI:10.1177/1756286418774254