Administration of cyclodextrin-ferulic acid complex significantly increases the plasma concentration of the intact form of ferulic acid in mice

• Published in: FOOD SCIENCE AND TECHNOLOGY RESEARCH Vol. 30; no. 4; pp. 509 - 513
• Main Authors: Tsuda, Takanori, Tanaka, Junpei, Yamashita, Sana
• Format: Journal Article
• Language: English
• Published: Tsukuba Japanese Society for Food Science and Technology 01.01.2024; The Japanese Society for Food Science and Technology; Japan Science and Technology Agency
• Subjects: absorption; Adipose tissue; beige adipocyte; Bioavailability; Body weight; Body weight gain; Cyclodextrin; cyclodextrin-complex; Cyclodextrins; Diet; Ferulic acid; Low fat diet; Nutrient deficiency
• ISSN: 1344-6606; 1881-3984
• DOI: 10.3136/fstr.FSTR-D-24-00017

We previously demonstrated that dietary ferulic acid (FA) (10 g FA/kg diet) significantly suppressed white adipose tissue (WAT) deposits and body weight gain via induction of beige adipocyte formation in mice. However, a lower dose of FA (2 g FA/kg diet) did not significantly suppress fat deposits or induce beige adipocyte formation due to low bioavailability. In the present study, we found that administration of α-cyclodextrin-FA complex (CD-FA) to mice significantly elevated the FA concentration in plasma and inguinal WAT. In particular, CD-FA administration significantly increased the intact form of FA in plasma, suggesting that it can be expected to enhance the induction of beige adipocyte formation at a lower dose. However, a CD-FA-supplemented diet (12.4 g CD-FA/kg, including 2.0 g FA/kg) did not significantly induce beige adipocyte formation. To reduce the required functional dose of FA, the further development of bioavailable FA formulations should be investigated.