Targeting NMDA receptors in stroke: new hope in neuroprotection

• Published in: Molecular brain Vol. 11; no. 1; pp. 15 - 14
• Main Authors: Wu, Qiu Jing, Tymianski, Michael
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.03.2018; BioMed Central; BMC
• Subjects: Analysis; Death signaling complexes; Excitotoxicity; Ischemic stroke; N-methyl-D-aspartate; Neuroprotection; NMDA receptors; Pathological physiology; Patient outcomes; Review; Risk factors; Stroke; Neuroprotection; Ischemic stroke; NMDA receptors; Excitotoxicity; Death signaling complexes

NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on NMDAR-associated signaling complexes has identified importa...