Targeting NMDA receptors in stroke: new hope in neuroprotection

NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on NMDAR-associated signaling complexes has identified importa...

Full description

Saved in:
Bibliographic Details
Published inMolecular brain Vol. 11; no. 1; pp. 15 - 14
Main Authors Wu, Qiu Jing, Tymianski, Michael
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 13.03.2018
BioMed Central
BMC
Subjects
Analysis
Death signaling complexes
Excitotoxicity
Ischemic stroke
N-methyl-D-aspartate
Neuroprotection
NMDA receptors
Pathological physiology
Patient outcomes
Review
Risk factors
Stroke
Neuroprotection
Ischemic stroke
NMDA receptors
Excitotoxicity
Death signaling complexes
Online AccessGet full text

Cover

More Information
Summary:NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on NMDAR-associated signaling complexes has identified important death-signaling pathways linked to NMDARs. This led to the generation of inhibitors that inhibit these pathways downstream from the receptor without necessarily blocking NMDARs. This therapeutic approach may have fewer side effects and/or provide a wider therapeutic window for stroke as compared to the receptor antagonists. In this review, we highlight the key findings in the signaling cascades downstream of NMDARs and the novel promising therapeutics for ischemic stroke.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-018-0357-8