Autophagy and pulmonary disease

• Published in: Therapeutic Advances in Respiratory Disease Vol. 13; p. 1753466619890538
• Main Authors: Liao, Shi-xia, Sun, Peng-peng, Gu, Yan-hui, Rao, Xi-min, Zhang, Lan-ying, Ou-Yang, Yao
• Format: Book Review Journal Article
• Language: English
• Published: London, England SAGE Publications 2019; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Autophagy; Chronic obstructive pulmonary disease; Lung cancer; Lung diseases; Pulmonary fibrosis; Review; Signal transduction; lung cancer; autophagy; infectious lung disease; pulmonary artery hypertension; pulmonary disease; idiopathic pulmonary fibrosis; acute lung injury
• ISSN: 1753-4666; 1753-4658; 1753-4666
• DOI: 10.1177/1753466619890538

Autophagy is a process of cell self-renewal that is dependent on the degradation of the cytoplasmic proteins or organelles of lysosomes. Many diseases, such as metabolic diseases, cancer, neurodegenerative diseases, and lung diseases, have been confirmed to be associated with elevated or impaired levels of autophagy. At present, studies have found that autophagy participates in the regulation of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, acute lung injury, lung cancer, and other pulmonary diseases. Using recent literature on the signal transduction mechanisms of autophagy and the effects of autophagy signalling on lung diseases, this review intends to clarify the mechanisms of lung disease to guide the treatment of related diseases. The reviews of this paper are available via the supplemental material section.