Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis

• Published in: Archives of Dermatological Research Vol. 300; no. 3; pp. 107 - 113
• Main Authors: Langewouters, A. M. G., van Erp, P. E. J., de Jong, E. M. G. J., van de Kerkhof, P. C. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2008; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Biological and medical sciences; Case-Control Studies; Cell Separation; Dermatology; Female; Flow Cytometry; Humans; Killer Cells, Natural - immunology; Killer Cells, Natural - pathology; Lymphocyte Count; Lymphocyte Subsets - immunology; Lymphocyte Subsets - pathology; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Original Paper; Psoriasis - blood; Psoriasis - immunology; Psoriasis - pathology; Psoriasis. Parapsoriasis. Lichen; Psoriasis; T cells; Lymphocytes; Severity of disease; Peripheral blood; Human; Skin disease; Disease; Dermatology; Severity; Peripheral blood; Severity of disease; Cell subpopulation; Blood; T-Lymphocyte; Severe; Comparative study
• ISSN: 0340-3696; 1432-069X
• DOI: 10.1007/s00403-007-0819-9

In several studies peripheral blood T-cells have been quantified, yet few data are available on lymphocyte subsets in moderate-to-severe psoriasis (in terms of extent and activity of lesions) versus mild psoriasis. The objective is to compare lymphocyte subsets in peripheral blood of patients with moderate-to-severe disease (PASI-score ≥12) to patients with mild disease (PASI-score <12) and to healthy subjects. By means of flow cytometry method, lymphocytes in peripheral blood of 27 patients with psoriasis and 10 healthy controls were characterized. The absolute number of total lymphocytes was markedly decreased in patients with moderate-to-severe psoriasis as compared to patients with mild disease and normal subjects. Cellcounts of all analysed subsets were found to be increased in more severe psoriasis, except for CD8+CD45RO+ cells. The under-representation of CD8+CD45RO+ cells is compatible with the dynamics of acquired immunity, which requires a time log after the relapse of the lesions to differentiate from CD45RA+ naive cells.