Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer

After 25 years of its discovery in the rat brain, d-serine is a recognized modulator of synaptic plasticity and cognitive processes through its actions on the NMDA-glutamate receptor. Importantly, cognitive impairment is a core feature of conditions, such as schizophrenia, Alzheimer's disease,...

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Published inFrontiers in psychiatry Vol. 9; p. 14
Main Authors Guercio, Gerson D., Panizzutti, Rogerio
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.02.2018
Subjects
biomarker
cognitive enhancer
d-amino acid oxidase
glycine
Psychiatry
sodium benzoate
sodium benzoate
d-amino acid oxidase
biomarker
glycine
cognitive enhancer
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Summary:After 25 years of its discovery in the rat brain, d-serine is a recognized modulator of synaptic plasticity and cognitive processes through its actions on the NMDA-glutamate receptor. Importantly, cognitive impairment is a core feature of conditions, such as schizophrenia, Alzheimer's disease, depression, and aging, and is associated to disturbances in NMDA-glutamate receptors. The d-serine pathway has been associated with cognitive deficits and these conditions, and, for this reason, d-serine signaling is subject of intense research to probe its role in aiding diagnosis and therapy. Nevertheless, this has not resulted in new therapies being incorporated into clinical practice. Therefore, in this review we will address many questions that need to be solved by future studies, regarding d-serine pharmacokinetics, possible side effects, other strategies to modulate its levels, and combination with other therapies to increase its efficacy.
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Specialty section: This article was submitted to Psychopathology, a section of the journal Frontiers in Psychiatry
Reviewed by: Chieh-Hsin Lin, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Hsien-Yuan Lane, China Medical University, Taiwan
Edited by: Kenji Hashimoto, Chiba University, Japan
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2018.00014