Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA
Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus r...
Saved in:
| Published in | Frontiers in microbiology Vol. 9; p. 1675 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
24.07.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, internalization, or the nuclear import of viral ribonucleoprotein (vRNP); however, in NUP93-depleted cells, viral RNA accumulated in the nucleus. These results suggest that NUP93 is involved in the nuclear export of viral RNA. |
|---|---|
| AbstractList | Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, internalization, or the nuclear import of viral ribonucleoprotein (vRNP); however, in NUP93-depleted cells, viral RNA accumulated in the nucleus. These results suggest that NUP93 is involved in the nuclear export of viral RNA. Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, internalization, or the nuclear import of viral ribonucleoprotein (vRNP); however, in NUP93-depleted cells, viral RNA accumulated in the nucleus. These results suggest that NUP93 is involved in the nuclear export of viral RNA.Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, internalization, or the nuclear import of viral ribonucleoprotein (vRNP); however, in NUP93-depleted cells, viral RNA accumulated in the nucleus. These results suggest that NUP93 is involved in the nuclear export of viral RNA. |
| Author | Yamada, Shinya Furusawa, Yuri Kawaoka, Yoshihiro |
| AuthorAffiliation | 1 Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan 2 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, WI , United States 3 Department of Special Pathogens, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan |
| AuthorAffiliation_xml | – name: 3 Department of Special Pathogens, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan – name: 1 Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan – name: 2 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, WI , United States |
| Author_xml | – sequence: 1 givenname: Yuri surname: Furusawa fullname: Furusawa, Yuri – sequence: 2 givenname: Shinya surname: Yamada fullname: Yamada, Shinya – sequence: 3 givenname: Yoshihiro surname: Kawaoka fullname: Kawaoka, Yoshihiro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30087672$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kctrVDEUh4NUbG27dyVZupnx5HFzk41QSh8DpYJacRdy82hT7tyMyb2D9q83M1NLK5hFEpLvfOfA7y3aG9LgEXpHYM6YVB_DMtpuToHIORDRNq_QARGCzxjQH3vP7vvouJR7qIsDrfsbtM8AZCtaeoC-XqYy4nNjx5Tx9WR7n1YpxwErhhcFL4Z16tfe4foy3vkdYTI--1WpEadQidBPfngw-HvMU8Ffrk-O0Otg-uKPH89DdHN-9u30cnb1-WJxenI1sw2V40yExhjmibO2I6p1lHvXcJBUqRCcooJI3lnmuOINYdJbFbgJwrPWtsoKww7RYud1ydzrVY5Lk3_rZKLePqR8q00eY51Yt8AIFQ3twDgeOi6pcdA5aSRYq6Strk8712rqlt5ZP4zZ9C-kL3-GeKdv01oLENUrquDDoyCnn5Mvo17GYn3fm8GnqWgKshEtSAkVff-811OTv6lUAHaAzamU7MMTQkBvstfb7PUme73NvpaIf0psHM0Y02ba2P-_8A8UibQe |
| CitedBy_id | crossref_primary_10_1042_ETLS20200232 crossref_primary_10_1080_02648725_2023_2191081 crossref_primary_10_3390_v13122409 crossref_primary_10_7717_peerj_7697 crossref_primary_10_1139_bcb_2018_0394 crossref_primary_10_26508_lsa_202201371 crossref_primary_10_1128_JVI_01888_19 crossref_primary_10_1002_asia_202101215 crossref_primary_10_1007_s13337_024_00879_6 crossref_primary_10_3389_fmicb_2022_895779 |
| Cites_doi | 10.1073/pnas.0437841100 10.1016/0092-8674(85)90157-6 10.1016/j.cell.2013.02.027 10.1152/ajplung.00011.2014 10.1016/j.celrep.2015.09.042 10.1126/science.aac7420 10.1128/JVI.03109-13 10.1016/j.chom.2014.11.002 10.1099/vir.0.037648-0 10.1007/BF02123572 10.1038/nature07151 10.1128/MCB.18.11.6826 10.1186/gb-2006-7-10-r100 10.1074/mcp.M113.028688 10.1083/jcb.150.4.695 10.1186/1743-422X-11-154 10.1091/mbc.8.10.2017 10.1091/mbc.E09-12-1041 10.1111/j.1600-0854.2006.00507.x 10.1006/excr.1998.4136 10.1371/journal.pone.0124651 10.1128/JVI.75.1.408-419.2001 10.1093/emboj/19.24.6751 10.1083/jcb.200704174 10.1091/mbc.E11-09-0761 |
| ContentType | Journal Article |
| Copyright | Copyright © 2018 Furusawa, Yamada and Kawaoka. 2018 Furusawa, Yamada and Kawaoka |
| Copyright_xml | – notice: Copyright © 2018 Furusawa, Yamada and Kawaoka. 2018 Furusawa, Yamada and Kawaoka |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fmicb.2018.01675 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1664-302X |
| ExternalDocumentID | oai_doaj_org_article_70312652b0ad4fb482ad0bd8a80cc98c PMC6066526 30087672 10_3389_fmicb_2018_01675 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: HHSN272201400008C |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK ECGQY GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 PGMZT RNS RPM IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c528t-6f5aa3e1dccb197d24ed5408299ffd926184bc3d4945138ec9f4af6e37c79c6a3 |
| IEDL.DBID | M48 |
| ISSN | 1664-302X |
| IngestDate | Wed Aug 27 01:28:48 EDT 2025 Thu Aug 21 14:06:06 EDT 2025 Fri Jul 11 09:08:13 EDT 2025 Thu Apr 03 07:05:30 EDT 2025 Tue Jul 01 00:55:14 EDT 2025 Thu Apr 24 23:03:40 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | host factor nuclear export A549 Nucleoporin 93 influenza A virus |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c528t-6f5aa3e1dccb197d24ed5408299ffd926184bc3d4945138ec9f4af6e37c79c6a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Yanmin Wan, University of Nebraska-Lincoln, United States; Peirong Jiao, South China Agricultural University, China; Taiki Aoshi, Osaka University, Japan This article was submitted to Virology, a section of the journal Frontiers in Microbiology Edited by: Masako Nomaguchi, Tokushima University Graduate School of Medical Sciences, Japan |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fmicb.2018.01675 |
| PMID | 30087672 |
| PQID | 2085670880 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_70312652b0ad4fb482ad0bd8a80cc98c pubmedcentral_primary_oai_pubmedcentral_nih_gov_6066526 proquest_miscellaneous_2085670880 pubmed_primary_30087672 crossref_primary_10_3389_fmicb_2018_01675 crossref_citationtrail_10_3389_fmicb_2018_01675 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-07-24 |
| PublicationDateYYYYMMDD | 2018-07-24 |
| PublicationDate_xml | – month: 07 year: 2018 text: 2018-07-24 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in microbiology |
| PublicationTitleAlternate | Front Microbiol |
| PublicationYear | 2018 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Terry (B22) 2007; 178 Yeganeh (B25) 2015; 308 Santos-Rosa (B20) 1998; 18 Munier (B14) 2013; 12 Liu (B12) 2015; 10 Sträßer (B21) 2000; 150 Tobita (B23) 1975; 162 Elton (B5) 2001; 75 Larsen (B11) 2014; 11 Ge (B6) 2003; 100 Daniels (B4) 1985; 40 Grandi (B7) 1997; 8 Chug (B3) 2015; 350 Kudo (B10) 1998; 242 Amorim (B1) 2007; 8 Sachdev (B19) 2012; 23 Oka (B16) 2010; 21 Killip (B9) 2014; 88 Neumann (B15) 2000; 19 Morita (B13) 2013; 153 Ozawa (B17) 2011; 92 Watanabe (B24) 2014; 16 Carpenter (B2) 2006; 7 Hao (B8) 2008; 454 Port (B18) 2015; 13 9683540 - Exp Cell Res. 1998 Aug 1;242(2):540-7 25909503 - PLoS One. 2015 Apr 24;10(4):e0124651 24478437 - J Virol. 2014 Apr;88(8):3942-52 11119609 - J Virol. 2001 Jan;75(1):408-19 17132145 - Traffic. 2007 Jan;8(1):1-11 25361566 - Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L270-86 26292704 - Science. 2015 Oct 2;350(6256):106-10 17076895 - Genome Biol. 2006;7(10):R100 23477864 - Cell. 2013 Mar 28;153(1):112-25 3967299 - Cell. 1985 Feb;40(2):431-9 26489467 - Cell Rep. 2015 Oct 27;13(4):690-702 17875746 - J Cell Biol. 2007 Sep 24;178(7):1121-32 9774696 - Mol Cell Biol. 1998 Nov;18(11):6826-38 18615016 - Nature. 2008 Aug 14;454(7206):890-3 12594334 - Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2718-23 9348540 - Mol Biol Cell. 1997 Oct;8(10):2017-38 23816991 - Mol Cell Proteomics. 2013 Oct;12(10):2845-55 20375145 - Mol Biol Cell. 2010 Jun 1;21(11):1885-96 11118210 - EMBO J. 2000 Dec 15;19(24):6751-8 21880840 - J Gen Virol. 2011 Dec;92(Pt 12):2879-88 25168591 - Virol J. 2014 Aug 28;11:154 1214709 - Med Microbiol Immunol. 1975 Dec 30;162(1):9-14 25464832 - Cell Host Microbe. 2014 Dec 10;16(6):795-805 22171326 - Mol Biol Cell. 2012 Feb;23(4):740-9 10952996 - J Cell Biol. 2000 Aug 21;150(4):695-706 |
| References_xml | – volume: 100 start-page: 2718 year: 2003 ident: B6 article-title: RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0437841100 – volume: 40 start-page: 431 year: 1985 ident: B4 article-title: Fusion mutants of the influenza virus hemagglutinin glycoprotein. publication-title: Cell doi: 10.1016/0092-8674(85)90157-6 – volume: 153 start-page: 112 year: 2013 ident: B13 article-title: The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. publication-title: Cell doi: 10.1016/j.cell.2013.02.027 – volume: 308 start-page: L270 year: 2015 ident: B25 article-title: Suppression of influenza a virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1. publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00011.2014 – volume: 13 start-page: 690 year: 2015 ident: B18 article-title: Structural and functional characterization of CRM1-Nup214 interactions reveals multiple FG-binding sites involved in nuclear export. publication-title: Cell Rep. doi: 10.1016/j.celrep.2015.09.042 – volume: 350 start-page: 106 year: 2015 ident: B3 article-title: Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex. publication-title: Science doi: 10.1126/science.aac7420 – volume: 88 start-page: 3942 year: 2014 ident: B9 article-title: Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export. publication-title: J. Virol. doi: 10.1128/JVI.03109-13 – volume: 16 start-page: 795 year: 2014 ident: B24 article-title: Influenza virus-host interactome screen as a platform for antiviral drug development. publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.11.002 – volume: 92 start-page: 2879 year: 2011 ident: B17 article-title: Replication-incompetent influenza a viruses that stably express a foreign gene. publication-title: J. Gen. Virol. doi: 10.1099/vir.0.037648-0 – volume: 162 start-page: 9 year: 1975 ident: B23 article-title: Plaque assay and primary isolation of influenza a viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin. publication-title: Med. Microbiol. Immunol. doi: 10.1007/BF02123572 – volume: 454 start-page: 890 year: 2008 ident: B8 article-title: Drosophila RNAi screen identifies host genes important for influenza virus replication. publication-title: Nature doi: 10.1038/nature07151 – volume: 18 start-page: 6826 year: 1998 ident: B20 article-title: Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.18.11.6826 – volume: 7 year: 2006 ident: B2 article-title: CellProfiler: image analysis software for identifying and quantifying cell phenotypes. publication-title: Genome Biol. doi: 10.1186/gb-2006-7-10-r100 – volume: 12 start-page: 2845 year: 2013 ident: B14 article-title: Exploration of binary virus-host interactions using an infectious protein complementation assay. publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M113.028688 – volume: 150 start-page: 695 year: 2000 ident: B21 article-title: Binding of the Mex67p/Mtr2p heterodimer to Fxfg, Glfg, and Fg repeat nucleoporins is essential for nuclear mRNA export. publication-title: J. Cell Biol. doi: 10.1083/jcb.150.4.695 – volume: 11 year: 2014 ident: B11 article-title: Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export. publication-title: Virol. J. doi: 10.1186/1743-422X-11-154 – volume: 8 start-page: 2017 year: 1997 ident: B7 article-title: Nup 93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.8.10.2017 – volume: 21 start-page: 1885 year: 2010 ident: B16 article-title: The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E09-12-1041 – volume: 8 start-page: 1 year: 2007 ident: B1 article-title: Nuclear export of influenza a virus mrnas requires ongoing RNA polymerase II activity. publication-title: Traffic doi: 10.1111/j.1600-0854.2006.00507.x – volume: 242 start-page: 540 year: 1998 ident: B10 article-title: Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. publication-title: Exp. Cell Res. doi: 10.1006/excr.1998.4136 – volume: 10 year: 2015 ident: B12 article-title: A Functional role of fibroblast growth factor recepTor 1 (FGFR1) in the suppression of influenza a virus replication. publication-title: PLoS One doi: 10.1371/journal.pone.0124651 – volume: 75 start-page: 408 year: 2001 ident: B5 article-title: Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. publication-title: J. Virol. doi: 10.1128/JVI.75.1.408-419.2001 – volume: 19 start-page: 6751 year: 2000 ident: B15 article-title: Influenza a virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. publication-title: EMBO J. doi: 10.1093/emboj/19.24.6751 – volume: 178 start-page: 1121 year: 2007 ident: B22 article-title: Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex. publication-title: J. Cell Biol. doi: 10.1083/jcb.200704174 – volume: 23 start-page: 740 year: 2012 ident: B19 article-title: The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E11-09-0761 – reference: 17875746 - J Cell Biol. 2007 Sep 24;178(7):1121-32 – reference: 21880840 - J Gen Virol. 2011 Dec;92(Pt 12):2879-88 – reference: 25168591 - Virol J. 2014 Aug 28;11:154 – reference: 18615016 - Nature. 2008 Aug 14;454(7206):890-3 – reference: 20375145 - Mol Biol Cell. 2010 Jun 1;21(11):1885-96 – reference: 10952996 - J Cell Biol. 2000 Aug 21;150(4):695-706 – reference: 9683540 - Exp Cell Res. 1998 Aug 1;242(2):540-7 – reference: 1214709 - Med Microbiol Immunol. 1975 Dec 30;162(1):9-14 – reference: 24478437 - J Virol. 2014 Apr;88(8):3942-52 – reference: 23477864 - Cell. 2013 Mar 28;153(1):112-25 – reference: 25464832 - Cell Host Microbe. 2014 Dec 10;16(6):795-805 – reference: 25361566 - Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L270-86 – reference: 11118210 - EMBO J. 2000 Dec 15;19(24):6751-8 – reference: 11119609 - J Virol. 2001 Jan;75(1):408-19 – reference: 9348540 - Mol Biol Cell. 1997 Oct;8(10):2017-38 – reference: 12594334 - Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2718-23 – reference: 22171326 - Mol Biol Cell. 2012 Feb;23(4):740-9 – reference: 17132145 - Traffic. 2007 Jan;8(1):1-11 – reference: 17076895 - Genome Biol. 2006;7(10):R100 – reference: 26292704 - Science. 2015 Oct 2;350(6256):106-10 – reference: 3967299 - Cell. 1985 Feb;40(2):431-9 – reference: 23816991 - Mol Cell Proteomics. 2013 Oct;12(10):2845-55 – reference: 25909503 - PLoS One. 2015 Apr 24;10(4):e0124651 – reference: 26489467 - Cell Rep. 2015 Oct 27;13(4):690-702 – reference: 9774696 - Mol Cell Biol. 1998 Nov;18(11):6826-38 |
| SSID | ssj0000402000 |
| Score | 2.242185 |
| Snippet | Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1675 |
| SubjectTerms | A549 host factor influenza A virus Microbiology nuclear export Nucleoporin 93 |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhUMil9JG2TtOgQi49uJFlPY9pyLIpdA9JU3ITetKFYod9lLa_Php5s-yG0F56lcdYzIznYY2_D6Fj7bwVTLKacZVq1jpXa0p8LUkEwG8lUwM_OH-ZiPE1-3zDbzaovmAmbIAHHhR3AvjqVHDqiA0sOaaoDcQFZRXxXisP0TfnvI1mqsRgaIsIGc4lcxems5mm3sEol_oIk_d8Kw8VuP7HasyHo5IbuWf0DD1dFY34dNjsc7QTuxfoyUAj-fsluhr38wUeFeYcPAGA4v4W5uqwbvHFHF90OQT9jAHnlVzuDRJ2hs9_Qe2N-5QlClPJH4u_TWfLOb6cnO6j69H517NxvSJLqD2nalGLxK1tYxO8d42WgbIYeGGT1ikFTYHYxfk2MM1406rodWI2idhKL7UXtn2Fdru-i28QtkB160ljnbK538vGpEnYJpc6UYjcMVfo5F51xq-QxIHQ4ofJHQUo2xRlG1C2Kcqu0If1HbcDisZfZD-BNdZygH9dFrJXmJVXmH95RYXe39vS5PcFDkFsF_vl3AAnqZA5tpIKvR5su35UWwD6JK2Q3LL61l62r3TT7wWTG_pATsXB_9j8W7QH6oAvyJQdot3FbBnf5dJn4Y6Kl98BdJwBTA priority: 102 providerName: Directory of Open Access Journals |
| Title | Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30087672 https://www.proquest.com/docview/2085670880 https://pubmed.ncbi.nlm.nih.gov/PMC6066526 https://doaj.org/article/70312652b0ad4fb482ad0bd8a80cc98c |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCNRLxbOER2UkLhxSEsfx44BQQV22SN0DsGhvkZ_tSlVSkl3U9tfjcbILi1YcuOTgjJVoxmPP2OPvQ-i11EYxymlKS-FTWmidSpKZlGcOAL8F9zlccD6dsPGUfp6Vs9_XowcFdltTO-CTmrYXh1c_rt8Hh38HGWdYb4MF5kZDlZY4hKL68ja6E9YlDm56OgT7cV6GVCnL-rPKrR130b0iYrRxsrFMRTT_bSHo35WUfyxNo_tob4gp8VE_CB6gW65-iO72LJPXj9DXcdMt8CgS6-AJ4Bc3l1B2h2WBTzp8UocZ6qezOLSEaLCXUC0-vgKt4MYHiUhkcqPw93m77PCXydFjNB0df_s4TgcuhdSURCxS5kulCpdbY3QuuSXU2TKSTUvvrSTA-6JNYamkZV4IZ6SnyjNXcMOlYap4gnbqpnZPEVbAhGuyXGmhQjoYbE08U3mIhBxjIaFO0NuV6iozAI0D38VFFRIO0HsV9V6B3quo9wS9Wfe47EE2_iH7AayxlgN47NjQtGfV4G0VgPITVhKdKUu9poIom2krlMiMkcIk6NXKllVwJzgjUbVrll0FlKWMh6k3S9B-b9v1p1ZjI0F8w-ob_7L5pp6fR8huSBNLwp79d8_naBd0ALvKhL5AO4t26V6GcGihD-I2Qnh-muUHccT_AmgmC0E |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Host+Factor+Nucleoporin+93+Is+Involved+in+the+Nuclear+Export+of+Influenza+Virus+RNA&rft.jtitle=Frontiers+in+microbiology&rft.au=Furusawa%2C+Yuri&rft.au=Yamada%2C+Shinya&rft.au=Kawaoka%2C+Yoshihiro&rft.date=2018-07-24&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-302X&rft.volume=9&rft_id=info:doi/10.3389%2Ffmicb.2018.01675&rft_id=info%3Apmid%2F30087672&rft.externalDocID=PMC6066526 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-302X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-302X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-302X&client=summon |