Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA

Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus r...

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Published inFrontiers in microbiology Vol. 9; p. 1675
Main Authors Furusawa, Yuri, Yamada, Shinya, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.07.2018
Subjects
A549
host factor
influenza A virus
Microbiology
nuclear export
Nucleoporin 93
host factor
nuclear export
A549
Nucleoporin 93
influenza A virus
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Summary:Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In this study, we focused on Nucleoporin 93 (NUP93) and revealed its importance in influenza virus replication. NUP93 knockdown mediated by siRNAs reduced viral replication and decreased the efficiency of the early step of the viral life cycle. NUP93 did not appear to be important for virus binding, internalization, or the nuclear import of viral ribonucleoprotein (vRNP); however, in NUP93-depleted cells, viral RNA accumulated in the nucleus. These results suggest that NUP93 is involved in the nuclear export of viral RNA.
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Reviewed by: Yanmin Wan, University of Nebraska-Lincoln, United States; Peirong Jiao, South China Agricultural University, China; Taiki Aoshi, Osaka University, Japan
This article was submitted to Virology, a section of the journal Frontiers in Microbiology
Edited by: Masako Nomaguchi, Tokushima University Graduate School of Medical Sciences, Japan
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.01675