Measurement of brain activity by near-infrared light

We review our most recent results on near-IR studies of human brain activity, which have been evolving in two directions: detection of neuronal signals and measurements of functional hemodynamics. We discuss results obtained so far, describing in detail the techniques we developed for detecting neur...

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Bibliographic Details
Published inJournal of biomedical optics Vol. 10; no. 1; p. 11008
Main Authors Gratton, Enrico, Toronov, Vladislav, Wolf, Ursula, Wolf, Martin, Webb, Andrew
Format Journal Article
LanguageEnglish
Published United States 01.01.2005
Subjects
Brain - cytology
Brain - physiology
Cerebrovascular Circulation - physiology
Hemodynamics
Humans
Infrared Rays
Magnetic Resonance Imaging
Neurons - physiology
Oxygen - blood
Spectroscopy, Near-Infrared
Time Factors
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Summary:We review our most recent results on near-IR studies of human brain activity, which have been evolving in two directions: detection of neuronal signals and measurements of functional hemodynamics. We discuss results obtained so far, describing in detail the techniques we developed for detecting neuronal activity, and presenting results of a study that, as we believe, confirms the feasibility of neuronal signal detection. We review our results on near-IR measurements of cerebral hemodynamics, which are performed simultaneously with functional magnetic resonance imaging (MRI) These results confirm the cerebral origin of hemodynamic signals measured by optical techniques on the surface of the head. We also show how near-IR methods can be used to study the underlying physiology of functional MRI signals.
ISSN:1083-3668
DOI:10.1117/1.1854673