Human Papillomavirus and Infertility

• Published in: Medicina (Kaunas, Lithuania) Vol. 55; no. 7; p. 377
• Main Authors: Jeršovienė, Vilma, Gudlevičienė, Živilė, Rimienė, Jolita, Butkauskas, Dalius
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.07.2019; MDPI AG
• Subjects: Adult; astenospermia; DNA Fingerprinting - methods; Female; HPV; Humans; in vitro fertilization; infertility; Infertility - epidemiology; Infertility - etiology; Infertility - genetics; Lithuania - epidemiology; Male; Middle Aged; Papillomaviridae - genetics; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Papillomavirus Infections - genetics; Prevalence; semen analysis; Spermatozoa - microbiology; Vaginal Smears - methods; Lithuania; astenospermia; in vitro fertilization; infertility; semen analysis; HPV
• ISSN: 1648-9144; 1010-660X; 1648-9144; 1010-660X
• DOI: 10.3390/medicina55070377

Background and objectives. Human papillomavirus (HPV) is the most commonly sexually transmitted infection. Recent evidence suggests that an HPV infection may affect fertility. The aim of the study was to determine the prevalence of HPV infections among couples undergoing in vitro fertilization (IVF) and to identify their awareness of HPV. Material and Methods. A total of 200 samples were collected from couples who received IVF treatment during 2017–2018 in Vilnius University Hospital Santaros Klinikos (VUH SK) Santaros Fertility Centre (SFC). For HPV detection, cervical swabs from women and sperm samples from men were taken and a real time polymerase chain reaction (RT-PCR) was used for the identification of 14 high-risk HPV types. Sperm parameters were evaluated according to World Health Organization (WHO) recommendations for 2010. Research subjects answered an anonymous questionnaire to ascertain their knowledge of HPV. Results. After testing of HPV in couples undergoing IVF, it was found that 33 out of 100 couples (33%) were HPV positive. Of these, 19% of women (19/100) and 20% of men (20/100) tested positive. Using Fisher’s exact test, a statistically significant difference was found between HPV infections and abnormal sperm quality parameters (p = 0.023). Conclusions. HPV may have an impact in spermatogenesis, because an HPV infection was more frequently detected in men with abnormal sperm parameters. High-risk HPV 52 was the most common genotype among couples undergoing IVF treatment.