Is Immune Modulation the Mechanism Underlying the Beneficial Effects of Amniotic Cells and Their Derivatives in Regenerative Medicine?

Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerati...

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Bibliographic Details
Published inCell transplantation Vol. 26; no. 4; pp. 531 - 539
Main Authors Silini, Antonietta R., Magatti, Marta, Cargnoni, Anna, Parolini, Ornella
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.04.2017
Sage Publications Ltd
SAGE Publishing
Subjects
Amnion - cytology
Amnion - immunology
Amnion - transplantation
Amniotic cells
Amniotic membrane
Animals
Humans
Immune response
Immunomodulation
Recovery of function
Regeneration
Regenerative Medicine
Review
Stromal cells
Translational Medical Research
Human placenta
Amniotic mesenchymal stromal/stem cells
Amniotic epithelial cells
Immune modulation
Paracrine mechanism
Amniotic membrane (AM)
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Summary:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate resident stem/stromal cells, and regeneration is possible only after the resolution of injury-induced inflammation. An exacerbated immune response is often present in cases of degenerative, inflammatory-based diseases. Here we discuss how amniotic membrane cells, and their derivatives, can contribute to the resolution of many diseases with altered immune response by acting on different inflammatory mediators.
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ISSN:0963-6897
1555-3892
DOI:10.3727/096368916X693699