Origin, evolution and genetic effects of nuclear insertions of organelle DNA

In eukaryotes, nuclear genomes are subject to an influx of DNA from mitochondria and plastids. The nuclear insertion of organellar sequences can occur during the illegitimate repair of double-stranded breaks. After integration, nuclear organelle DNA is modified by point mutations, and by deletions....

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Bibliographic Details
Published inTrends in genetics Vol. 21; no. 12; pp. 655 - 663
Main Author Leister, Dario
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.2005
Elsevier Science
Subjects
Biological and medical sciences
Cell Nucleus - genetics
Cell Nucleus - metabolism
Chloroplasts - genetics
Chloroplasts - metabolism
DNA - genetics
DNA - metabolism
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
Mitochondria - genetics
Mitochondria - metabolism
Molecular and cellular biology
Phylogeny
Plants - genetics
Plants - metabolism
Origin
Molecular evolution
Mitochondria
DNA
Cell nucleus
Insertion
Genetics
Mutation
Plastid
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Summary:In eukaryotes, nuclear genomes are subject to an influx of DNA from mitochondria and plastids. The nuclear insertion of organellar sequences can occur during the illegitimate repair of double-stranded breaks. After integration, nuclear organelle DNA is modified by point mutations, and by deletions. Insertion of organelle DNA into nuclear genes is not rare and can potentially have harmful effects. In humans, some insertions of nuclear mitochondrial DNA are associated with heritable diseases. It remains to be determined whether nuclear organelle DNA can contribute beneficially to gene evolution.
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ISSN:0168-9525
DOI:10.1016/j.tig.2005.09.004