MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 con...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 8; p. 1932
Main Authors Alivernini, Stefano, Gremese, Elisa, McSharry, Charles, Tolusso, Barbara, Ferraccioli, Gianfranco, McInnes, Iain B, Kurowska-Stolarska, Mariola
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.01.2018
Subjects
antibody production
arthritis rheumatoid
autoimmunity
Immunology
inflammation
microRNA-155
microRNA-155
antibody production
autoimmunity
inflammation
arthritis rheumatoid
Online AccessGet full text

Cover

More Information
Summary:MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Michael Bonelli, Medical University of Vienna, Austria; Devendra K. Agrawal, Creighton University, United States
Edited by: Massimo Gadina, National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.01932