Retrospective analysis of clinical characteristics of 405 patients with COVID-19

• Published in: Journal of international medical research Vol. 48; no. 8; p. 300060520949039
• Main Authors: Zhan, Ting, Liu, Meng, Tang, Yalin, Han, Zheng, Cheng, Xueting, Deng, Junsheng, Chen, Xiaoli, Tian, Xia, Huang, Xiaodong
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2020; Sage Publications Ltd; SAGE Publishing
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - physiology; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Betacoronavirus; C-Reactive Protein - analysis; China; Community-Acquired Infections - diagnosis; Community-Acquired Infections - pathology; Community-Acquired Infections - virology; Comorbidity; Coronavirus Infections - diagnosis; Coronavirus Infections - pathology; Coronavirus Infections - transmission; Coronaviruses; COVID-19; Disease; Female; Gastrointestinal Diseases - diagnosis; Gastrointestinal Diseases - pathology; Gastrointestinal Diseases - virology; Humans; Laboratories; Lymphocyte Count; Male; Middle Aged; Pandemics; Pneumonia, Viral - diagnosis; Pneumonia, Viral - pathology; Pneumonia, Viral - transmission; Retrospective Clinical Research Report; Retrospective Studies; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Young Adult; China; COVID-19; fever; SARS-CoV-2; clinical characteristics; Wuhan; gastrointestinal symptoms
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060520949039

Objective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. Results The patients’ median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. Conclusion SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.