Impact of Maternal Age on Oocyte and Embryo Competence

The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults, especially concerning an increased incidence...

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Published inFrontiers in endocrinology (Lausanne) Vol. 9; p. 327
Main Authors Cimadomo, Danilo, Fabozzi, Gemma, Vaiarelli, Alberto, Ubaldi, Nicolò, Ubaldi, Filippo Maria, Rienzi, Laura
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.06.2018
Subjects
aging
aneuploidies
Endocrinology
IVF
oocyte competence
ovarian reserve
IVF
oocyte competence
aging
ovarian reserve
aneuploidies
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Summary:The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults, especially concerning an increased incidence of aneuploidies and possibly decreased mitochondrial activity. Age-related chromosomal abnormalities mainly arise because of meiotic impairments during oogenesis, following flawed chromosome segregation patterns such as non-disjunction, premature separation of sister chromatids, or the recent reverse segregation. In this review, we briefly discuss the main mechanisms putatively impaired by aging in the oocytes and the deriving embryos. We also report the main strategies proposed to improve the management of advanced maternal age women in IVF: fertility preservation through oocyte cryopreservation to prevent aging; optimization of the ovarian stimulation and enhancement of embryo selection to limit its effects; and oocyte donation to circumvent its consequences.
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Specialty section: This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology
Edited by: Sandro C. Esteves, Androfert, Andrology and Human Reproduction Clinic, Brazil
Reviewed by: Hakan Yarali, Anatolia IVF, Turkey; Jung Ryeol Lee, Seoul National University College of Medicine, South Korea; Matheus Roque, ORIGEN – Center for Reproductive Medicine, Brazil
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2018.00327