Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

• Published in: Frontiers in microbiology Vol. 10; p. 294
• Main Authors: Pan, Rui, Bai, Xuelian, Chen, Jianwei, Zhang, Huawei, Wang, Hong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.02.2019
• Subjects: co-cultivation; epigenetic modification; medium composition; microbe secondary metabolite; Microbiology; OSMAC strategy; structural diversity; epigenetic modification; microbe secondary metabolite; co-cultivation; OSMAC strategy; medium composition; structural diversity

Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery h...