Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery h...

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Published inFrontiers in microbiology Vol. 10; p. 294
Main Authors Pan, Rui, Bai, Xuelian, Chen, Jianwei, Zhang, Huawei, Wang, Hong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.02.2019
Subjects
co-cultivation
epigenetic modification
medium composition
microbe secondary metabolite
Microbiology
OSMAC strategy
structural diversity
epigenetic modification
microbe secondary metabolite
co-cultivation
OSMAC strategy
medium composition
structural diversity
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Summary:Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents.
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SourceType-Scholarly Journals-1
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Reviewed by: Juan Carlos Aon, GlaxoSmithKline, United States; Anil Shrestha, Ewha Womans University, South Korea
This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
Edited by: Dipesh Dhakal, Sun Moon University, South Korea
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2019.00294