Stem cell therapy for neonatal hypoxic-ischemic encephalopathy

Treatments for neonatal hypoxic-ischemic encephalopathy (HIE) have been limited. The aim of this paper is to offer translational research guidance on stem cell therapy for neonatal HIE by examining clinically relevant animal models, practical stem cell sources, safety and efficacy of endpoint assays...

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Published inFrontiers in neurology Vol. 5; p. 147
Main Authors Gonzales-Portillo, Gabriel S, Reyes, Stephanny, Aguirre, Daniela, Pabon, Mibel M, Borlongan, Cesar V
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2014
Subjects
Cerebral Palsy
combination therapy
Hypothermia
Neuroscience
Stem Cells
Translational research
cerebral palsy
stem cells
combination therapy
translational research
hypothermia
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Summary:Treatments for neonatal hypoxic-ischemic encephalopathy (HIE) have been limited. The aim of this paper is to offer translational research guidance on stem cell therapy for neonatal HIE by examining clinically relevant animal models, practical stem cell sources, safety and efficacy of endpoint assays, as well as a general understanding of modes of action of this cellular therapy. In order to do so, we discuss the clinical manifestations of HIE, highlighting its overlapping pathologies with stroke and providing insights on the potential of cell therapy currently investigated in stroke, for HIE. To this end, we draw guidance from recommendations outlined in stem cell therapeutics as an emerging paradigm for stroke or STEPS, which have been recently modified to Baby STEPS to cater for the "neonatal" symptoms of HIE. These guidelines recognized that neonatal HIE exhibit distinct disease symptoms from adult stroke in need of an innovative translational approach that facilitates the entry of cell therapy in the clinic. Finally, new information about recent clinical trials and insights into combination therapy are provided with the vision that stem cell therapy may benefit from available treatments, such as hypothermia, already being tested in children diagnosed with HIE.
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Edited by: Anna Purna Basu, Newcastle University, UK
Reviewed by: Seongjin Yu, NHRI, Taiwan; Takao Yasuhara, Okayama University, Japan
Gabriel S. Gonzales-Portillo, Stephanny Reyes and Daniela Aguirre have contributed equally to this work.
This article was submitted to Neuropediatrics, a section of the journal Frontiers in Neurology.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2014.00147