Influencing Factors of Thermogenic Adipose Tissue Activity

Obesity is an escalating public health challenge and contributes tremendously to the disease burden globally. New therapeutic strategies are required to alleviate the health impact of obesity-related metabolic dysfunction. Brown adipose tissue (BAT) is specialized for dissipating chemical energy for...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in physiology Vol. 7; p. 29
Main Authors Zhang, Guoqing, Sun, Qinghua, Liu, Cuiqing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.02.2016
Subjects
Air Pollution
Brite/beige adipocytes
brown adipose tissue
Obesity
Physiology
Thermogenesis
brite/beige adipocytes
thermogenesis
air pollution
brown adipose tissue
obesity
Online AccessGet full text

Cover

More Information
Summary:Obesity is an escalating public health challenge and contributes tremendously to the disease burden globally. New therapeutic strategies are required to alleviate the health impact of obesity-related metabolic dysfunction. Brown adipose tissue (BAT) is specialized for dissipating chemical energy for thermogenesis as a defense against cold environment. Intriguingly, the brown-fat like adipocytes that dispersed throughout white adipose tissue (WAT) in rodents and humans, called "brite" or "beige" adipocytes, share similar thermogenic characteristics to brown adipocytes. Recently, researchers have focused on cognition of these thermogenic adipose tissues. Some factors have been identified to regulate the development and function of thermogenic adipose tissues. Cold exposure, pharmacological conditions, and lifestyle can enhance non-shivering thermogenesis and metabolism via some mechanisms. However, environmental pollutants, such as ambient fine particulates and ozone, may impair the function of these thermogenic adipose tissues and thereby induce metabolic dysfunction. In this review, the origin, function and influencing factors of thermogenic adipose tissues were summarized and it will provide insights into identifying new therapeutic strategies for the treatment of obesity and obesity-related diseases.
Bibliography:Edited by: Luigi Iuliano, Sapienza University of Rome, Italy
This article was submitted to Lipidology, a section of the journal Frontiers in Physiology
Reviewed by: Fabien Gosselet, Artois University, France; Alessandro Laviano, Sapienza University of Rome, Italy
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2016.00029