Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

• Published in: Journal of dental research Vol. 94; no. 12; pp. 1698 - 1705
• Main Authors: Singer, R.E., Moss, K., Kim, S.J., Beck, J.D., Offenbacher, S.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.12.2015; SAGE PUBLICATIONS, INC
• Subjects: Arteriosclerosis; Atherosclerosis; Bacteria; Binding sites; Biofilms; C-reactive protein; C-Reactive Protein - analysis; C-Reactive Protein - physiology; Cardiovascular disease; Clinical outcomes; Clinical trials; Dentistry; Dinoprost - analogs & derivatives; Dinoprost - blood; Dinoprost - physiology; Family medical history; Female; Gum disease; Humans; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - physiology; Immunoglobulins; Inflammation; Inflammatory diseases; Lipids; Male; Middle Aged; Mouth - microbiology; Oxidative stress; Oxidative Stress - physiology; Periodontal diseases; Periodontitis; Periodontitis - blood; Periodontitis - immunology; Periodontitis - physiopathology; Premature birth; Prospective Studies; Research Reports; Serum levels; Systemic diseases; Variables; biostatistics; host pathogen interaction; immunity; bacteria; biomarkers; acute phase reaction
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/0022034515602693

In a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum IgG antibodies to oral bacteria. The association between increased serum IgG with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. Other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic C-reactive protein (CRP) response. These observations led us to hypothesize that the reported relationship of periodontitis to elevated serum CRP, a systemic inflammatory marker, may be modified by oxidative stress and that the levels of serum antibodies to oral bacteria might be an intermediary explanatory variable linking the association of systemic oxidative stress, periodontal disease, and levels of CRP. This hypothesis was explored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using serum levels of CRP, serum IgG levels to 16 oral organisms, serum levels of 8-isoprostane, and periodontal status. The findings indicate periodontitis is associated with high CRP in the presence of elevated oxidative stress that serves to suppress the IgG response. Only within the highest 8-isoprostane quartile was periodontitis (pocket depth) associated with increased serum CRP levels (P = 0.0003). Increased serum IgG antibody levels to oral bacteria were associated with lowered serum CRP levels. Thus, systemic oxidative stress, which has been demonstrated to be associated with increased levels of CRP in other studies, appears to be associated with the suppression of bacterial-specific IgG levels, which in the presence of periodontal disease can result in an enhanced systemic CRP response. Conversely, individuals with increased serum IgG antibodies to plaque bacteria exhibit lowered serum CRP levels. These 2 factors, oxidative stress and the serum IgG response, appear to function in opposing directions to modify serum levels of CRP and the association with periodontitis.