Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder

• Published in: Digestive and liver disease Vol. 48; no. 3; pp. 248 - 254
• Main Authors: Fulceri, Francesca, Morelli, Mariangela, Santocchi, Elisa, Cena, Hellas, Del Bianco, Teresa, Narzisi, Antonio, Calderoni, Sara, Muratori, Filippo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2016
• Subjects: Abdominal Pain - epidemiology; Abdominal Pain - psychology; Aggression - psychology; Anxiety - epidemiology; Anxiety - psychology; Anxiety problems; Autism Spectrum Disorder - epidemiology; Autism Spectrum Disorder - psychology; Case-Control Studies; Child Behavior Checklist 1½–5; Child, Preschool; Comorbidity; Constipation - epidemiology; Constipation - psychology; Diarrhea - epidemiology; Diarrhea - psychology; Externalizing problems; Female; Gastroenterology and Hepatology; Gastrointestinal Diseases - epidemiology; Gastrointestinal Diseases - psychology; Gut-brain axis; Humans; Infant; Male; Prevalence; Problem Behavior - psychology; Externalizing problems; Anxiety problems; Gut-brain axis; Child Behavior Checklist 1½–5
• ISSN: 1590-8658; 1878-3562; 1878-3562
• DOI: 10.1016/j.dld.2015.11.026

Gastrointestinal (GI) symptoms are frequently reported in children with Autism Spectrum Disorder (ASD), and an impact of GI comorbidity on ASD behavioral problems has been hypothesized. To explore the type and the prevalence of GI symptoms in ASD patients and typical development (TD) controls, and to investigate their possible association with behavioral problems. A total of 230 preschoolers were included in this study. Specifically, four groups of children were evaluated: ASD individuals suffering from GI symptoms (ASD/GI+), ASD subjects without GI symptoms (ASD/GI−), TD peers with (TD/GI+) and without (TD/GI−) GI symptoms. Parental report of behavioral problems and GI symptoms were assessed through the Child Behavior Check List 1½–5. A significant higher percentage of ASD (37.4%) versus TD (14.8%) with GI symptoms was observed. ‘Constipated’ and ‘Not-Eat’ were the most frequent GI symptoms both in ASD and in TD groups, but they were evaluated as more severe in ASD patients. ASD/GI+ children had more anxiety problems, somatic complaints, externalizing and total problems than ASD/GI− individuals. TD/GI+ did not show more behavioral problems than TD/GI−. Development of evidence-based guidelines for identification of GI problems in ASD preschoolers is warranted. GI symptomatology should be accurately assessed, especially in ASD children with anxiety and/or externalizing behavioral problems.