Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 7
• Main Authors: Ferda, Jiří, Schmidt, Bernhard, Moláček, Jiří, Štěpánková, Lucie, Šedivý, Jakub, Hromádka, Milan, Baxa, Jan, Flohr, Thomas G.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acquisitions & mergers; Algorithms; Angiography; Automation; Blood Pressure; Cardiology; Cardiovascular disease; Coronary Angiography; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - physiopathology; Coronary vessels; CT imaging; Female; Heart Rate; Humans; Male; Medical imaging; Middle Aged; Myocardial Perfusion Imaging; Patient outcomes; Patients; Physiological aspects; Purines - pharmacology; Pyrazoles - pharmacology; Quality; Stenosis; Studies; Tomography, X-Ray Computed; Vascular surgery; Veins & arteries; Czech Republic; Germany
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/105629

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p=0.002; per-vessel: specificity 95 versus 75%, p=0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.