Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke

Atrial fibrillation (AF) increases the risk of ischemic stroke and systemic arterial embolism. However, the risk factors or predictors of stroke in AF patients have not been clarified. Therefore, it is necessary to find effective diagnostic and therapeutic targets. Two datasets were downloaded from...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neurology Vol. 11; p. 184
Main Authors Zhang, Yan-fei, Meng, Ling-bing, Hao, Meng-lei, Yang, Jie-fu, Zou, Tong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.03.2020
Subjects
atrial fibrillation
bioinformatic technology
differentially expressed genes
hub genes
Neurology
stroke
differentially expressed genes
atrial fibrillation
hub genes
stroke
bioinformatic technology
Online AccessGet full text

Cover

More Information
Summary:Atrial fibrillation (AF) increases the risk of ischemic stroke and systemic arterial embolism. However, the risk factors or predictors of stroke in AF patients have not been clarified. Therefore, it is necessary to find effective diagnostic and therapeutic targets. Two datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differently expressed genes (DEGs) were identified between samples of atrial fibrillation without stroke and atrial fibrillation with stroke. Enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) by Gene Set Enrichment Analysis (GSEA), construction and analysis of protein-protein interaction (PPI) network and significant module, and the receiver operator characteristic (ROC) curve analysis were performed. A total of 524 DEGs were common to both datasets. Analysis of KEGG pathways indicated that the top canonical pathways associated with DEGs were ubiquitin-mediated proteolysis, endocytosis, spliceosome, and so on. Ten hub genes (SMURF2, CDC42, UBE3A, RBBP6, CDC5L, NEDD4L, UBE2D2, UBE2B, UBE2I, and MAPK1) were identified from the PPI network and were significantly associated with a diagnosis of atrial fibrillation and stroke (AFST). In summary, a total of 524 DEGs and 10 hub genes were identified between samples of atrial fibrillation without stroke and atrial fibrillation with stroke. These genes may serve as the target of early diagnosis or treatment of AF complicated by stroke.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Simona Lattanzi, Marche Polytechnic University, Italy; Joylene Elisabeth Siland, University of Groningen, Netherlands
Edited by: Maurizio Acampa, Siena University Hospital, Italy
This article was submitted to Stroke, a section of the journal Frontiers in Neurology
These authors have contributed equally to this work
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.00184