Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring
The aim of this study was to investigate if environmentally relevant doses of the putative estrogenic non dioxin-like PCB 153 and the dioxin-like PCB 126 caused changes in bone tissue in female goat offspring following perinatal exposure. Goat dams were orally dosed with PCB 153 in corn oil (98 μg/k...
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Published in | Toxicology (Amsterdam) Vol. 228; no. 1; pp. 33 - 40 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
10.11.2006
Amsterdam Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of this study was to investigate if environmentally relevant doses of the putative estrogenic non dioxin-like PCB 153 and the dioxin-like PCB 126 caused changes in bone tissue in female goat offspring following perinatal exposure. Goat dams were orally dosed with PCB 153 in corn oil (98
μg/kg body wt/day) or PCB 126 (49
ng/kg body wt/day) from day 60 of gestation until delivery. The offspring were exposed to PCB
in utero and through mother's milk. The suckling period lasted for 6 weeks. Offspring metacarpal bones were analysed using peripheral quantitative computed tomography (pQCT) after euthanisation at 9 months of age. The diaphyseal bone was analysed at a distance of 18% and 50% of the total bone length, and the metaphyseal bone at a distance of 9%. Also, biomechanical three-point bending of the bones was conducted, with the load being applied to the mid-diaphyseal pQCT measure point (50%). PCB 153 exposure significantly decreased the total cross-sectional area (125
mm
2
±
4) versus non-exposed (142
mm
2
±
5), decreased the marrow cavity (38
mm
2
±
4) versus non-exposed (50
mm
2
±
3) and decreased the moment of resistance (318
mm
3
±
10) versus non-exposed (371
mm
3
±
20) at the diaphyseal 18% measure point. At the metaphyseal measure point, the trabecular bone mineral density (121
mg/cm
3
±
5) was increased versus non-exposed (111
mg/cm
3
±
3). PCB 126 exposure did not produce any observable changes in bone tissue. The biomechanical testing of the bones did not show any significant changes in bone strength after PCB 153 or PCB 126 exposure. In conclusion, perinatal exposure to PCB 153, but not PCB 126, resulted in altered bone composition in female goat offspring. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0300-483X 1879-3185 1879-3185 |
DOI: | 10.1016/j.tox.2006.08.016 |