Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly

Dendritic cells (DCs) play an important role in advancing age-associated progressive decline in adaptive immune responses, loss of tolerance, and development of chronic inflammation. In aged humans, DCs secrete increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory...

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Published inFrontiers in immunology Vol. 8; p. 896
Main Authors Agrawal, Anshu, Agrawal, Sudhanshu, Gupta, Sudhir
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.07.2017
Subjects
aging
dendritic cells
Immunology
inflammation
mucosa
tolerance
dendritic cells
aging
inflammation
mucosa
tolerance
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Summary:Dendritic cells (DCs) play an important role in advancing age-associated progressive decline in adaptive immune responses, loss of tolerance, and development of chronic inflammation. In aged humans, DCs secrete increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory and immune-regulatory cytokines. This may contribute to both chronic inflammation and loss of tolerance in aging. Aged DCs also display increased immune response against self-antigens contributing further to both inflammation and loss of tolerance. The secretion of innate protective cytokines such as type I and III interferons is decreased, and the function of DCs in airway remodeling and inflammation in aged is also compromised. Furthermore, the capacity of DCs to prime T cell responses also seems to be affected. Collectively, these changes in DC functions contribute to the immune dysfunction and inflammation in the elderly. This review only focuses on age-associated changes in DC function in humans.
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Edited by: Peter Katsikis, Erasmus University Rotterdam, Netherlands
Specialty section: This article was submitted to Immunological Memory, a section of the journal Frontiers in Immunology
Reviewed by: Wolfgang Kastenmüller, University of Bonn, Germany; Yvonne Mueller, Erasmus Medical Center, Netherlands
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.00896