Inhibition of rat liver cytosol casein kinases by heparin

The experiments also disclosed an inhibition by heparin of the monomeric type I casein kinase, Ck-S, which was expected to be insensitive to it: such an inhibition however requires concentrations of heparin 200-300-times higher than those effective on Ck-TS and occurs through a different mechanism,...

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Bibliographic Details
Published inFEBS letters Vol. 141; no. 2; pp. 257 - 262
Main Authors Meggio, F., Donella Deana, A., Brunati, A.M., Pinna, L.A.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 17.05.1982
Subjects
Animals
Binding, Competitive
casein kinase
Casein Kinases
cytosol
Cytosol - enzymology
heparin
Heparin - pharmacology
Isoenzymes - antagonists & inhibitors
Kinetics
liver
Liver - enzymology
Protein Kinase Inhibitors
Rats
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Summary:The experiments also disclosed an inhibition by heparin of the monomeric type I casein kinase, Ck-S, which was expected to be insensitive to it: such an inhibition however requires concentrations of heparin 200-300-times higher than those effective on Ck-TS and occurs through a different mechanism, as it can be apparently reversed by high ATP concentration but neither by casein nor by phosvitin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(82)80061-6