Unstructured model for growth of mycelial pellets in submerged cultures [Fungus Penicillium chrysogenum]

• Published in: Biotechnology and bioengineering Vol. 24; no. 1; p. 177
• Main Authors: van Suijdam, J C, Hols, H, Kossen, N W
• Format: Journal Article
• Language: English
• Published: United States 1982
• ISSN: 0006-3592; 1097-0290
• DOI: 10.1002/bit.260240115

An unstructured model is presented to describe growth of mycelial pellets in submerged cultures. This model integrates growth kinetics at the scale of the hyphae with the physical mechanisms of mass-transfer processes at the scale of the pellets and the fermentor. The main elements of the model are biomass, substrate, and oxygen balances for the liquid phase and the pellets. The possible occurrence of oxygen limitation in the pellets is introduced in analogy with catalyst theories by means of an effectiveness factor. To simulate the growth of pellets the model is transferred into a computer program. The model is tested by means of fermentation experiments in a bubble column. Results of the growth experiments compare favorably with the outcome of computer simulations.