A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucle...

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Bibliographic Details
Published inFEBS letters Vol. 582; no. 27; pp. 3832 - 3838
Main Authors Vacher, C.-M., Crépin, D., Aubourg, A., Couvreur, O., Bailleux, V., Nicolas, V., Férézou, J., Gripois, D., Gertler, A., Taouis, M.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 12.11.2008
Wiley
Subjects
Animals
Appetite Regulation - drug effects
Appetite Regulation - genetics
Arcuate nucleus
Arcuate Nucleus of Hypothalamus - metabolism
Ciliary Neurotrophic Factor - administration & dosage
Ciliary Neurotrophic Factor - genetics
Ciliary Neurotrophic Factor - physiology
Ciliary Neurotrophic Factor Receptor alpha Subunit - genetics
Ciliary Neurotrophic Factor Receptor alpha Subunit - physiology
CNTF
Cognitive science
Energy Metabolism - drug effects
Energy Metabolism - genetics
Female
Food intake
Gene Expression
Genetic Predisposition to Disease
Homeostasis
Male
Mitogen-Activated Protein Kinase Kinases - metabolism
Neuroscience
Obesity
Obesity - genetics
Obesity - prevention & control
Phosphorylation
Rats
Rats, Wistar
Recombinant Proteins - biosynthesis
Unbalanced diet
Weight Gain - drug effects
Weight Gain - genetics
Obesity
CNTF
Food intake
Unbalanced diet
Arcuate nucleus
unbalanced diet
cntf
arcuate nucleus
obesity
food intake
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Summary:Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2008.10.018