Report on IL‐10 gene polymorphism at position –819 for major depression and schizophrenia in Korean population

• Published in: Psychiatry and clinical neurosciences Vol. 56; no. 2; pp. 177 - 180
• Main Authors: Jun, Tae‐Youn, Pae, Chi‐Un, Chae, Jeong‐Ho, Bahk, Won‐Myong, Kim, Kwang‐Soo, Han, Hoon
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Asia Pty. Ltd 01.04.2002; Blackwell Publishing
• Subjects: Adult and adolescent clinical studies; association study; Biological and medical sciences; Depression; Depressive Disorder - ethnology; Depressive Disorder - genetics; Depressive Disorder - physiopathology; DNA - analysis; Genetic factors; Genetic Predisposition to Disease; Genotype; Humans; IL‐10 gene; Interleukin-10 - genetics; Interleukin-10 - pharmacology; Korea; major depression; Medical sciences; Mood disorders; Polymerase Chain Reaction; polymorphism; Polymorphism, Genetic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - ethnology; Schizophrenia - genetics; Schizophrenia - physiopathology; Tropical medicine; Asia; Korea; Mood disorder; Social environment; Human; Molecular position; Cytokine; Schizophrenia; Depression; Genotype; Genetic determinism; Psychosis; Polymerase chain reaction; Restriction fragment length polymorphism; Interleukin 10; Genetics; Molecular biology; Comparative study
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1046/j.1440-1819.2002.00943.x

The present study was carried out to examine the relationship of interleukin (IL)‐10 gene polymorphism at position –819 for major depression and schizophrenia in the Korean population. DNA was extracted from 92 Korean patients with major depression, 141 Korean patients with schizophrenia, and 146 ethnically matched controls. DNA was amplified by a polymerase chain reaction‐based method and digested by MaeIII, and the restriction fragment length polymorphism of two alleles, IL‐10*C and IL‐10*T, were assessed. There were no significant differences in genotype frequencies of IL‐10*T/T, IL‐10*T/C, and IL‐10*C/C as well as allelic frequencies of IL‐10*T and IL‐10*C between patients with major depression and controls in the Korean population. Comparison of genotype and allelic frequencies of IL‐10 gene between patients with schizophrenia and controls were also not significant. The present study suggests that IL‐10 gene polymorphism at position –819 does not confer susceptibility to major depression and schizophrenia, at least in the Korean population. Further systematic studies including various clinical variables would be required.