Effect of dopamine transporter genotype on caudate volume in childhood ADHD and controls
Polymorphism of the dopamine transporter genotype (DAT1) confers a small but significant susceptibility to attention deficit hyperactivity disorder (ADHD). We examined whether the volume of the head of caudate, a striatal structure with high DAT expression that is important for inhibitory function,...
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Published in | American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 156B; no. 1; pp. 28 - 35 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.01.2011
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Polymorphism of the dopamine transporter genotype (DAT1) confers a small but significant susceptibility to attention deficit hyperactivity disorder (ADHD). We examined whether the volume of the head of caudate, a striatal structure with high DAT expression that is important for inhibitory function, differs by DAT1 in children diagnosed with the disorder relative to age and IQ matched controls. Volume of the head of caudate was delineated in the right and left hemisphere and compared between 7‐ and 13‐year‐old children with and without ADHD (combined type) who were carriers of two (10/10) or one (9/10) copy of the 10‐repeat DAT1 allele. Caudate volumes were overall smaller in 10/10 than 9/10 children, particularly in the left than right hemisphere. While DAT1 effects did not vary by ADHD diagnosis, overall caudate volumes were smaller in ADHD relative to control children. Altered caudate development associated with 10‐repeat homozygosity of DAT1 may contribute susceptibility to ADHD. © 2010 Wiley‐Liss, Inc. |
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Bibliography: | NIMH - No. MH065395; No. MH70564 ark:/67375/WNG-V2HZTR60-N istex:177FA07503C5BCDB33F815F3E0A7D55BEC2C1CD6 ArticleID:AJMG31132 How to Cite this Article: Shook D, Brady C, Lee PS, Kenealy L, Murphy ER, Gaillard WD, VanMeter JW, Cook E, Stein M, Vaidya CJ. 2011. Effect of Dopamine Transporter Genotype on Caudate Volume in Childhood ADHD and Controls. Am J Med Genet Part B 156:28-35. How to Cite this Article: Shook D, Brady C, Lee PS, Kenealy L, Murphy ER, Gaillard WD, VanMeter JW, Cook E, Stein M, Vaidya CJ. 2011. Effect of Dopamine Transporter Genotype on Caudate Volume in Childhood ADHD and Controls. Am J Med Genet Part B 156:28–35. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1552-4841 1552-485X 1552-485X |
DOI: | 10.1002/ajmg.b.31132 |