Consequences of direct and indirect activation of dendritic cells on antigen presentation: Functional implications and clinical considerations

• Published in: Molecular immunology Vol. 55; no. 2; pp. 175 - 178
• Main Authors: Vega-Ramos, Javier, Villadangos, José A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2013
• Subjects: Antigen Presentation; Dendritic cell; dendritic cells; Dendritic Cells - immunology; Histocompatibility Antigens Class II - immunology; Humans; immune response; Lymphocyte Activation; Pathogen; Ubiquitin-Protein Ligases - biosynthesis; Ubiquitin-Protein Ligases - immunology; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Antigen Presentation; Pathogen; Dendritic cell
• ISSN: 0161-5890; 1872-9142; 1872-9142
• DOI: 10.1016/j.molimm.2012.10.034

► Recent works on the regulation of antigen presentation by dendritic cells after activation/maturation are reviewed. ► We review recent findings showing that indirectly activated DC retain their capacity to present subsequently encountered antigens. ► Functional implications and clinical considerations of the reviewed subjects. The antigen presentation properties of Dendritic cells (DC) are key factors in the initiation and modulation of immune responses. The mechanisms involved in the regulation of MHC II antigen presentation in DC have been thoroughly investigated. Here, we will summarize recent advances in the field, focusing on how DC regulate antigen presentation during and after maturation, and its functional implications. We will also discuss future perspectives and clinical considerations.