Primary Hyperparathyroidism Associated with Multiple Myeloma

• Published in: Internal Medicine Vol. 34; no. 10; pp. 988 - 991
• Main Authors: GOTO, Shin, YOSHIOKA, Mitsuaki, NAGAI, Koichi, ABE, Atsushi, MURAKAWA, Eizo, YAMAZAKI, Nobuyasu, KOYAMA, Takanobu, SEKIYA, Masao
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1995; Japanese Society of Internal Medicine
• Subjects: Adenoma - diagnosis; Adenoma - surgery; Aged; Biological and medical sciences; Diagnosis, Differential; Endocrinopathies; Fatal Outcome; Female; Humans; hypercalcemia; Hypercalcemia - blood; Hypercalcemia - etiology; Hyperparathyroidism - etiology; light chain myeloma; Medical sciences; Multiple Myeloma - complications; Multiple Myeloma - diagnosis; Non tumoral diseases. Target tissue resistance. Benign neoplasms; parathyroid adenoma; Parathyroid Neoplasms - diagnosis; Parathyroid Neoplasms - surgery; Parathyroidectomy; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases); Recurrence; Endocrinopathy; Human; Hypercalcemia; Immunopathology; Association; Immunoglobulinopathy; Parathyroid diseases; Lymphoproliferative syndrome; Malignant hemopathy; Myeloma; Elderly; Hyperparathyroidism
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.34.988

A 73-year-old woman was diagnosed as primary hyperparathyroidism. Hypercalcemia recurred after parathyroidectomy, though serum calcium concentration temporarily resumed to normal. Hypercalcemia was eventually shown to be due to multiple myeloma. In spite of the frequent association of hypercalcemia with malignant disease and the relative frequency of primary hyperparathyroidism as a cause of hypercalcemia, primary hyperparathyroidism accompanied by multiple myeloma has been considered in only a limited number of reports. Here, the cases in the literature are reviewed and discussed. (Internal Medicine 34: 988-991, 1995)