3D-Printed Chips: Compatibility of Additive Manufacturing Photopolymeric Substrata with Biological Applications

Additive manufacturing (AM) is ideal for building adaptable, structurally complex, three-dimensional, monolithic lab-on-chip (LOC) devices from only a computer design file. Consequently, it has potential to advance micro- to milllifluidic LOC design, prototyping, and production and further its appli...

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Bibliographic Details
Published inMicromachines (Basel) Vol. 9; no. 2; p. 91
Main Authors Carve, Megan, Wlodkowic, Donald
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.02.2018
MDPI
Subjects
3D printing
Additive manufacturing
bioassay
Biocompatibility
Biomedical materials
Computer design
lab-on-a-chip
polymers
Prototyping
Review
Three dimensional printing
Toxicity
toxicity
bioassay
additive manufacturing
polymers
lab-on-a-chip
3D printing
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Summary:Additive manufacturing (AM) is ideal for building adaptable, structurally complex, three-dimensional, monolithic lab-on-chip (LOC) devices from only a computer design file. Consequently, it has potential to advance micro- to milllifluidic LOC design, prototyping, and production and further its application in areas of biomedical and biological research. However, its application in these areas has been hampered due to material biocompatibility concerns. In this review, we summarise commonly used AM techniques: vat polymerisation and material jetting. We discuss factors influencing material biocompatibility as well as methods to mitigate material toxicity and thus promote its application in these research fields.
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These authors contributed equally to this work.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi9020091