Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep

In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration of IEDs at the scalp and co...

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Published inScientific reports Vol. 10; no. 1; p. 1673
Main Authors Kang, Xuan, Boly, Melanie, Findlay, Graham, Jones, Benjamin, Gjini, Klevest, Maganti, Rama, Struck, Aaron F.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.02.2020
Nature Publishing Group
Subjects
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692/308/53/2423
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Adult
Cerebral cortex
EEG
Electroencephalography - methods
Epilepsy
Epilepsy - physiopathology
Eye movements
Female
Humanities and Social Sciences
Humans
Localization
Male
multidisciplinary
NREM sleep
Polysomnography - methods
REM sleep
Scalp - physiopathology
Science
Science (multidisciplinary)
Sleep
Sleep, REM - physiology
Sleep, Slow-Wave - physiology
Spatial distribution
Statistical analysis
Surgery
Temporal distribution
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Summary:In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration of IEDs at the scalp and cortical levels using HD-EEG source-localization, during non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monitoring unit admission. Statistical analyses were performed at single subject level and group level across different sleep stages for duration and distribution of IEDs. Tests were corrected for multiple comparisons across all channels and time points. Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spatially more restricted. Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrographic ictal onset zone from scalp EEG recording. This study supports the localizing value of REM IEDs over NREM IEDs and suggests that HD-EEG may be of clinical utility in epilepsy surgery work-up.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-58612-4