A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in surveillance, epidemiology, and end results (SEER) database

• Published in: BMC cancer Vol. 20; no. 1; pp. 666 - 10
• Main Authors: Jia, Bo, Zheng, Qiwen, Wang, Jingjing, Sun, Hongyan, Zhao, Jun, Wu, Meina, An, Tongtong, Wang, Yuyan, Zhuo, Minglei, Li, Jianjie, Yang, Xue, Zhong, Jia, Chen, Hanxiao, Chi, Yujia, Zhai, Xiaoyu, Wang, Ziping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.07.2020; BioMed Central; BMC
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Analysis; Calibration; Cancer research; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cell death; Chemoradiotherapy, Adjuvant - statistics & numerical data; Chemotherapy; Codes; Datasets; Epidemiology; Ethnicity; Female; Follow-Up Studies; Gender; Health aspects; Humans; Lung - pathology; Lung - surgery; Lung cancer; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Lymph nodes; Lymphatic system; Male; Medical prognosis; Middle Aged; Mortality; Neoplasm Staging; Nomogram; Nomograms; Non-small cell lung cancer; Non-small cell lung carcinoma; NSCLC; Patients; Pneumonectomy; Population; Probability; Prognosis; Radiation therapy; Risk Factors; SEER; SEER Program - statistics & numerical data; Small cell lung cancer; Small cell lung carcinoma; Statistical analysis; Studies; Surgery; Surveillance; Survival Rate; United States - epidemiology; Young Adult; United States; SEER; Prognosis; NSCLC; Nomogram; Surgery
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-020-07147-y

This study aimed to establish a novel nomogram prognostic model to predict death probability for non-small cell lung cancer (NSCLC) patients who received surgery.. We collected data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute in the United States. A nomogram prognostic model was constructed to predict mortality of NSCLC patients who received surgery. A total of 44,880 NSCLC patients who received surgery from 2004 to 2014 were included in this study. Gender, ethnicity, tumor anatomic sites, histologic subtype, tumor differentiation, clinical stage, tumor size, tumor extent, lymph node stage, examined lymph node, positive lymph node, type of surgery showed significant associations with lung cancer related death rate (P < 0.001). Patients who received chemotherapy and radiotherapy had significant higher lung cancer related death rate but were associated with significant lower non-cancer related mortality (P<0.001). A nomogram model was established based on multivariate models of training data set. In the validation cohort, the unadjusted C-index was 0.73 (95% CI, 0.72-0.74), 0.71 (95% CI, 0.66-0.75) and 0.69 (95% CI, 0.68-0.70) for lung cancer related death, other cancer related death and non-cancer related death. A prognostic nomogram model was constructed to give information about the risk of death for NSCLC patients who received surgery.