Improvement of anemia in five dogs with nonregenerative anemia treated with allogeneic adipose-derived stem cells

• Published in: Veterinary and animal science Vol. 17; p. 100264
• Main Authors: Mizuno, Takuya, Inoue, Misuzu, Kubo, Takeaki, Iwaki, Yoshihide, Kawamoto, Kosuke, Itamoto, Kazuhito, Kambayashi, Satoshi, Igase, Masaya, Baba, Kenji, Okuda, Masaru
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2022; Elsevier
• Subjects: Adipose-derived stem cells; Allogenic; anemia; animal science; blood transfusion; Canine; immunosuppression; Mesenchymal stem cells; Nonregenerative anemia; Allogenic; Nonregenerative anemia; Adipose-derived stem cells; Canine; Mesenchymal stem cells
• ISSN: 2451-943X; 2451-943X
• DOI: 10.1016/j.vas.2022.100264

•Five canine cases with nonregenerative anemia were included in this study.•All were treated with allogeneic adipose-derived stem cells (ADSCs).•All cases showed improvement of anemia by ADSCs treatment. Nonregenerative anemia is occasionally seen in dogs and can be caused by many factors, among which nonregenerative immune-mediated anemia (NRIMA) and pure red cell anemia are relatively common causes. These are thought to be caused by immune-mediated destruction of the erythroid lineage and are treated with immunosuppressive drugs, but some of them are refractory or recurrent, so new treatments are needed. To examine the efficacy of allogeneic adipose-derived stem cells (ADSCs) for the treatment of nonregerative anemia in dogs. ADSCs were administered to total five nonregenerative anemia cases; two NRIMA cases and two suspected NRIMA cases that were refractory to immunosuppressive agents, and one NRIMA case that has not been treated with immunosuppressive agents. In all cases, anemia was improved, and blood transfusion was no longer necessary. This study suggests that allogeneic ADSCs may be one of the rescue therapies for the refractory immune-mediated anemia in dogs.