Driving mesenchymal stem cell differentiation from self-assembled monolayers
The utilization of self-assembled monolayer (SAM) systems to direct Mesenchymal Stem Cell (MSC) differentiation has been covered in the literature for years, but finding a general consensus pertaining to its exact role over the differentiation of stem cells had been rather challenging. Although ther...
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| Published in | RSC advances Vol. 8; no. 12; pp. 6551 - 6564 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
01.01.2018
The Royal Society of Chemistry |
| Subjects | |
| Online Access | Get full text |
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| Summary: | The utilization of self-assembled monolayer (SAM) systems to direct Mesenchymal Stem Cell (MSC) differentiation has been covered in the literature for years, but finding a general consensus pertaining to its exact role over the differentiation of stem cells had been rather challenging. Although there are numerous reports on surface functional moieties activating and inducing differentiation, the results are often different between reports due to the varying surface conditions, such as topography or surface tension. Herein, in view of the complexity of the subject matter, we have sought to catalogue the recent developments around some of the more common functional groups on predominantly hard surfaces and how these chemical groups may influence the overall outcome of the mesenchymal stem cells (MSC) differentiation so as to better establish a clearer underlying relationship between stem cells and their base substratum interactions.
Graphical illustration showing the functional groups that drive MSC differentiation without soluble bioactive cues within the first 14 days. |
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| Bibliography: | Lih Shin Tew was born in the Malaysian state of Penang in 1992. She completed her Bachelor Degree in Biomedical Science at Universiti Tunku Abdul Rahman (UTAR) in 2016. She is currently pursuing her Master's degree in Science at the Universiti Sains Malaysia (USM) under the supervision of Dr Siti Hawa Ngalim and Dr Yit Lung Khung and is currently writing up her Master's thesis. Her work is mainly focused on silicon surface modification and cell-surface interaction. Siti Hawa Ngalim's research interest is in tuning cell adhesion and migration via extracellular physicochemical cues. She received her PhD in 2013 from the University of New South Wales, Sydney, Australia, under the tutelage of Prof. Katharina Gaus. Since then, she has been working as a University lecturer/primary investigator at the Universiti Sains Malaysia, Penang. She was a guest researcher in the lab of Prof. Michiyuki Matsuda of Kyoto University in 2015, developing a new FRET sensor for cell migration study in C2C12. She has been working as a guest researcher under Dr Elisabetta Ada Cavalcanti-Adam of Max Planck Institute for Medical Research, Heidelberg Germany, since December 2016. Currently, she and her group are actively doing research on: (1) stem cell-like cells (C2C12 cells) activity on bone morphogenetic protein (BMP) immobilized on spatially-controlled gold nanoparticles, (2) cellular uptake activity of normal gut epithelial cells (CCD 184 CoN cells) on micropatterned surfaces. Jing Yuan Ching was born in Malaysia in 1994. She received her Bachelor's degree in Biological Science and Technology from China Medical University, Taiwan in 2017. Currently, she is studying her Master's degree in the same University under the supervision of Dr Yit Lung Khung. Her research interests include silicon surface modification and cell-surface interactions. Yit Lung Khung was born in Singapore in 1976. He received his PhD in Physical Sciences from Flinders University in 2009 under Prof. Nicolas Hans Voelcker examining porous silicon-based biomaterials. Subsequently, he joined the University of New South Wales as an ARC postdoctoral fellow from 2008-2009, followed shortly after by a term at Nanyang Technological University as NRF postdoctoral researcher working in the areas of nanoparticle drug delivery. From 2012-2015, he worked at the University of Milan-Bicocca in Italy as an EU researcher with Prof. Dario Narducci on Silicon Chemistry before being appointed as a faculty member at the department of Biological Sciences at China Medical University (Taiwan) in November 2015. His research interests include defining surface bond formation on silicon substrates, cell-surface interaction and the study of self-assembled monolayers on silicon at the nanometre level. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3 |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/c7ra12234a |