Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation

• Published in: Scientific reports Vol. 10; no. 1; p. 2737
• Main Authors: Whoolery, Cody W., Yun, Sanghee, Reynolds, Ryan P., Lucero, Melanie J., Soler, Ivan, Tran, Fionya H., Ito, Naoki, Redfield, Rachel L., Richardson, Devon R., Shih, Hung-ying, Rivera, Phillip D., Chen, Benjamin P. C., Birnbaum, Shari G., Stowe, Ann M., Eisch, Amelia J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2020; Nature Publishing Group
• Subjects: 631/378; 631/532; Animals; Astronauts; Biobehavioral Sciences; Circuits; Cognition & reasoning; Cognition - physiology; Cognition - radiation effects; Cognitive ability; Cosmic Radiation; Dentate gyrus; Dentate Gyrus - physiology; Dentate Gyrus - radiation effects; Functional morphology; Humanities and Social Sciences; Interactive computer systems; Iron Isotopes; Irradiation; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Neurogenesis; Neurons - cytology; Neurons - physiology; Neurons - radiation effects; Paired-Associate Learning - physiology; Paired-Associate Learning - radiation effects; Pattern Recognition, Visual - physiology; Pattern Recognition, Visual - radiation effects; Reversal learning; Reversal Learning - physiology; Reversal Learning - radiation effects; Rodents; Science; Science (multidisciplinary); Space Flight; Spatial discrimination learning; Visual discrimination; Visual discrimination learning; Visual pathways; Whole-Body Irradiation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-59419-z

Astronauts on interplanetary missions - such as to Mars - will be exposed to space radiation, a spectrum of highly-charged, fast-moving particles that includes 56 Fe and 28 Si. Earth-based preclinical studies show space radiation decreases rodent performance in low- and some high-level cognitive tasks. Given astronaut use of touchscreen platforms during training and space flight and given the ability of rodent touchscreen tasks to assess functional integrity of brain circuits and multiple cognitive domains in a non-aversive way, here we exposed 6-month-old C57BL/6J male mice to whole-body space radiation and subsequently assessed them on a touchscreen battery. Relative to Sham treatment, 56 Fe irradiation did not overtly change performance on tasks of visual discrimination, reversal learning, rule-based, or object-spatial paired associates learning, suggesting preserved functional integrity of supporting brain circuits. Surprisingly, 56 Fe irradiation improved performance on a dentate gyrus-reliant pattern separation task; irradiated mice learned faster and were more accurate than controls. Improved pattern separation performance did not appear to be touchscreen-, radiation particle-, or neurogenesis-dependent, as 56 Fe and 28 Si irradiation led to faster context discrimination in a non-touchscreen task and 56 Fe decreased new dentate gyrus neurons relative to Sham. These data urge revisitation of the broadly-held view that space radiation is detrimental to cognition.