In Vitro Fertilization with Preimplantation Genetic Screening

• Published in: The New England journal of medicine Vol. 357; no. 1; pp. 9 - 17
• Main Authors: Mastenbroek, Sebastiaan, Twisk, Moniek, van Echten-Arends, Jannie, Sikkema-Raddatz, Birgit, Korevaar, Johanna C, Verhoeve, Harold R, Vogel, Niels E.A, Arts, Eus G.J.M, de Vries, Jan W.A, Bossuyt, Patrick M, Buys, Charles H.C.M, Heineman, Maas Jan, Repping, Sjoerd, van der Veen, Fulco
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 05.07.2007
• Subjects: Adult; Age; Aneuploidy; Biological and medical sciences; Birth Rate; Chromosome Disorders - diagnosis; Chromosomes; Double-Blind Method; Embryo Transfer; Embryos; Female; Fertilization in Vitro; Follow-Up Studies; General aspects; Genetic Testing - methods; Genetics; Humans; In Situ Hybridization, Fluorescence; In vitro fertilization; Maternal Age; Medical sciences; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Preimplantation Diagnosis - adverse effects; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reproductive technologies; Sperm; Sperm Injections, Intracytoplasmic; In vitro fertilization embryo transfer; Medicine; Assisted procreation; Genetics; Medical screening
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa067744

It has been suggested that the use of preimplantation genetic screening of cleavage-stage embryos for aneuploidies may improve pregnancy rates in women of advanced maternal age undergoing in vitro fertilization (IVF). In this multicenter, double-blind, randomized trial, women 35 through 41 years of age assigned to preimplantation genetic screening had lower rates of ongoing pregnancies and live births than those undergoing IVF alone. These results argue against the routine use of preimplantation genetic screening as an adjunct to IVF in women of advanced maternal age. In this trial, women of advanced maternal age assigned to preimplantation genetic screening had lower rates of ongoing pregnancies and live births than those undergoing in vitro fertilization alone. The use of in vitro fertilization (IVF) has steadily increased over the past decade. The American and European registries of assisted reproductive technology reported a total of 352,769 initiated IVF cycles in the year 2002. 1 , 2 In about half of these cycles, the woman was 35 years of age or older, 1 , 2 reflecting the demographic trend toward postponement of the time to start a family. 3 Unfortunately, IVF by itself cannot compensate for the lower fecundity associated with increasing age. 3 A potential cause of the low pregnancy rates in women of advanced maternal age undergoing IVF is the increased incidence of . . .