Rapidly Progressive Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia

• Published in: Internal Medicine Vol. 33; no. 11; pp. 710 - 713
• Main Authors: ITO, Keiko, IWABE, Kouji, OKAI, Takahiro, KOUDA, Sizuo, TADOKORO, Masao, ISIKO, Tositaka
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1994; Japanese Society of Internal Medicine
• Subjects: Biological and medical sciences; cell-mediated immunity; Disease Progression; Hematologic and hematopoietic diseases; Humans; interferon-alpha; Interferon-alpha - therapeutic use; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lung - diagnostic imaging; Lung - pathology; Male; Medical sciences; Middle Aged; pulmonary alveolar phospholipoproteinosis; Pulmonary Alveolar Proteinosis - complications; Pulmonary Alveolar Proteinosis - diagnosis; Pulmonary Alveolar Proteinosis - immunology; Radiography; Time Factors; Human; Immunopathology; Lung disease; Respiratory disease; Malignant hemopathy; Cellular immunity; Case study; Myeloproliferative syndrome; Chemotherapy; Treatment; Proteinosis; Chronic myelocytic leukemia; Interstitial pneumonitis; Complication; Interferon
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.33.710

A 46-year-old man with chronic myelogenous leukemia (CML) was admitted to our hospital because of high fever. The chest radiographs showed bilateral groundglass-like infiltrates in the perihilar region. Transbronchial lung biopsy (TBLB) and autopsy revealed PAS-positive granular materials characteristic of pulmonary alveolar proteinosis (PAP). He had received interferonalpha since the time of CML diagnosis. Busulfan had never been administered. Altered cell-mediated immunity was thought to be closely related to the development of PAP. (Internal Medicine 33: 710-713, 1994)