Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability

The majority of environmental factors can not modify DNA sequence, but can influence the epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics to influence phenotypic variation and disease, suggests environmental epigenetics will have a critical role in disease e...

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Bibliographic Details
Published inEpigenetics Vol. 6; no. 7; pp. 838 - 842
Main Author Skinner, Michael K
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.07.2011
Subjects
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
DNA Methylation
Environmental Pollutants - adverse effects
Epigenesis, Genetic
Heredity - genetics
Humans
Landes
Mitosis - genetics
Organogenesis
Phenotype
Proteins
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Summary:The majority of environmental factors can not modify DNA sequence, but can influence the epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics to influence phenotypic variation and disease, suggests environmental epigenetics will have a critical role in disease etiology and biological areas such as evolutionary biology. The current review presents the molecular basis of how environment can promote stable epigenomes and modified phenotypes, and distinguishes the difference between epigenetic transgenerational inheritance through the germ line versus somatic cell mitotic stability.
ISSN:1559-2294
1559-2308
DOI:10.4161/epi.6.7.16537