Effect of calcium salts of a mixture of conjugated linoleic acids containing trans-10, cis-12 in the diet on milk fat synthesis in goats

• Published in: British journal of nutrition Vol. 101; no. 7; pp. 1006 - 1019
• Main Authors: Shingfield, Kevin J., Rouel, Jacques, Chilliard, Yves
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.04.2009; Cambridge University Press (CUP)
• Subjects: Animal Feed; animal feeding; animal nutrition; Animals; Biological and medical sciences; Calcium; Calcium - administration & dosage; calcium salts of palm oil fatty acids; Conjugated linoleic acid; Diet; Dietary Supplements; dose response; Dose-Response Relationship, Drug; Esters; experimental diets; fatty acid methyl esters; Fatty acids; Fatty Acids - analysis; Feeding. Feeding behavior; Female; Food and Nutrition; Fundamental and applied biological sciences. Psychology; goat milk; Goats; Goats - metabolism; Lactation; Lactation - physiology; Lactose - analysis; Life Sciences; Linoleic Acids, Conjugated - administration & dosage; Linoleic Acids, Conjugated - analysis; Lipids - biosynthesis; lipogenesis; Metabolism and Metabolic Studies; Milk; Milk - chemistry; Milk - metabolism; milk fat; Milk fat synthesis; milk fat yield; nutrient uptake; organic salts; Palm oil; palm oils; Salts; secretion; trans fatty acids; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Zea mays; Conjugated linoleic acid; Goats; Lactation; Milk fat synthesis; Conjugated linoleic acid: Milk fat synthesis: Goats: Lactation; Goat milk; Salt; Vertebrata; Mammalia; Calcium; Diet; Biosynthesis; Milk fat; Feeding; CONJUGATED LINOLEIC ACID; GOATS; ACIDE LINOLEIQUE; MILK FAT SYNTHESIS; LACTATION
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114508051696

Dietary supplements of conjugated linoleic acid (CLA) containing trans-10, cis-12 CLA decrease milk fat secretion in the lactating cow and sheep, but their effects on mammary lipogenesis in the goat are less well defined. Eight lactating goats were used in two 4 × 4 Latin-square experiments with 14 d experimental periods to examine the effects of calcium salts of CLA methyl esters (CaCLA) containing trans-10, cis-12 on milk fat synthesis. Experimental treatments consisted of incremental inclusion of 0, 30, 60 or 90 g of CaCLA/d (corresponding to 7·47, 14·9 and 22·4 g/d of trans-10, cis-12 CLA) offered during the first 10 d of each experimental period that replaced maize grain in concentrates (Experiment 1) or calcium salts of palm oil fatty acids (Experiment 2). Relative to the control, inclusion of 30, 60 or 90 g CaCLA/d in the diet reduced milk fat yield by 19·8, 27·9 and 32·3 % and 17·5, 39·0 and 49·3 % in Experiments 1 and 2, respectively. Decreases in milk fat were due to reductions in the secretion of fatty acids synthesised de novo rather than the uptake of fatty acids from the peripheral circulation. Indirect comparisons with the studies in the lactating cow indicated a lower efficacy of CaCLA supplements on mammary lipogenesis in the goat. In conclusion, CaCLA in the diet inhibits milk fat synthesis in the goat, responses that are dependent on the supply of dietary fatty acids, with evidence that the caprine is less sensitive to the anti-lipogenic effects of trans-10, cis-12 CLA compared with the bovine or ovine.